Featured in this article:
  • This game will be played at the Arizona Cardinals home stadium due to COVID-19 protocols.
  • The total has gone OVER in 8 of the Bills' last 11 games.
  • The total has gone UNDER in four of the 49ers last six games.

Buffalo nearly blew a 24-6 second half lead, but held off a pesky Chargers squad to secure the 27-17 win and improved to 8-3 straight up and 6-5 against the spread this season.

The 49ers completed the season sweep of the Rams courtesy of a Robbie Gould game-winning field goal as time expired. The 23-20 victory snapped a three-game losing streak and keeps San Francisco in the playoff hunt.

Week 13: Buffalo Bills vs San Francisco 49ers Game Info
Date: December 7, 2020, 8:15 p.m. ET
Stadium: State Farm Stadium (Arizona)
TV Coverage: ESPN
Opening Odds: 49ers +2.5 | O/U 48
How to Bet: Best Online Sportsbook Reviews

Line Movement

Note: Santa Clara County in California just enacted restrictions on ALL contact sports for the next three weeks due to a rise in COVID-19 cases. Thus, the San Francisco 49ers will play their next two home games at Arizona’s State Farm Stadium.

The Bills opened as 2.5-point road favorites when the game was initially scheduled to be played in Santa Clara, but Buffalo -3 seems to be the consensus spread as of press time. The 49ers moneyline is anywhere between +119 and +135. The point total opened and remains 48. The OVER has hit in eight of the Bills’ 11 games this season and four of five road games including a 32-30 loss in Arizona to the Cardinals.

This will be Buffalo’s second game at State Farm Stadium over the past three weeks.

The UNDER has hit in three of the 49ers past four games played at Arizona’s home stadium.

Bills News and Notes

If not for the Hail Murray, Buffalo is in the midst of a five-game winning streak heading into Week 13. It’s truly remarkable how much of an instant impact Stefon Diggs has injected into the passing game and lifted the overall confidence of Josh Allen. The fourth-year quarterback out of Wyoming is completing nearly 69 percent (up 10%) of his passes with 22 touchdowns (finished with 20 in 16 games last year) and 3,028 yards (finished with 3,089 last year). Diggs’ ability to stretch the field has also allowed slot receiver Cole Beasley to contribute more as he’s averaging a first down per reception.

Three consecutive turnovers in the fourth quarter of Week 12′ contest allowed the Chargers to claw their way back. And while holding Justin Herbert to 3-of-16 on third downs is commendable, Buffalo’s defense also yielded four-of-five fourth down attempts by Los Angeles. That type of sloppy play is what typically turns an Against-the-Spread win into a loss right quick.

49ers News and Notes

While Jimmy Garoppolo remains out indefinitely with an ankle sprain, and may not be the long-term solution at quarterback the 49ers had hoped, San Francisco is getting healthier with five games to go. Last week, Raheem Mostert, Jeff Wilson, Deebo Samuel and Richard Sherman all returned after extensive absences. Mostert scored the first touchdown of the game, Samuel caught 11 passes for 133 yards and Sherman led the team with seven tackles with an interception.

By adding these variables back into the offensive and defensive puzzle, it would be unwise to underestimate the strength of the 49ers down the stretch. Granted, they are still missing several key players on both sides of the football and COVID-19 is wreaking havoc with personnel and, now, game location. These headaches in addition to limited practice reps are a nightmare for Kyle Shanahan.

With Buffalo allowing nearly 130 rush yards per game, the return of Mostert & Wilson with a splash of Jerick McKinnon is critical to Monday night’s game plan. It’s not that Nick Mullens can’t carry some of the weight, but the 6:7 touchdown to interception ratio doesn’t evoke a lot of confidence. The running game and upgraded secondary will be the keys to a San Francisco upset home win on the road.

The 49ers are 1-5 overall and 2-4 against the spread in their last six games at Arizona’s home stadium.

Betting Pick: 49ers +3

With San Francisco getting healthy at the right time, they can compete with this rough-around-the-edges Bills team. The secondary will be one of the greater challenges Josh Allen faces this year. While unlucky to lose back-to-back home games when vying for a playoff spot in a competitive NFC West, I like San Francisco’s defense to lift up Nick Mullens and the 49ers offense this Monday night.

Check out our expert NFL betting guide if you want to learn more about How to Bet on Week 13 of the NFL or head right to our favorite online sportsbook review page and find the right site for you!

Ryan Fowler

Ryan has covered sports on every media platform over the past 17+ years. The first seven years of his professional career were spent as a sports anchor and reporter at various local television stations, while he picked up side gigs as a freelance sports columnist and recurring radio guest before he decided to jump to the web. As content manager of sports simulation website WhatIfSports.com and senior editor of FOXSports.com's fantasy baseball and football coverage for the better part of this decade, Ryan embraces advanced metrics, trends, and outside-the-box angles to find his edge. You can follow him on Twitter @FreelanceFowler.

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